Sort IV Collagen Chains

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Basement membranes are specialised extracellular matrices with guidance, sieving, and cell regulatory features. The molecular architectures of these matrices are designed through precise binding interactions among special glycoprotein and proteoglycan protomers. Laminin, a four-armed glycoprotein, self-assembles through terminal-domain interactions to sort a 2nd polymer community, Entactin/nidogen, a dumbbell-formed sulfated glycoprotein, binds laminin near its center and interacts with variety IV collagen, bridging the two. Form IV collagen chains, working with NH2-terminal, COOH-terminal, and lateral affiliation, kind a covalently stabilized polygonal framework.

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