Hairless Triggers Reactivation Of Hair Development By Advertising Wnt Signaling
Here, we show that transgenic expression of HR in progenitor keratinocytes rescues follicle regeneration in Hr -/- mice. This work backlinks HR and Wnt purpose, supplying a product in which HR regulates the exact timing of Wnt signaling required for hair follicle regeneration. The Hairless (Hr) gene encodes a nuclear receptor corepressor (HR) that is vital for hair follicle regeneration, but its role in this method is not known. We display that expression of Clever, a modulator of Wnt signaling, is repressed by HR in these cells, coincident with the timing of follicle regeneration. The mammalian hair cycle includes periodic regeneration of a very small organ, the hair follicle, by means of a stem-mobile-mediated approach.
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