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Recently, Holstege et al. reported the intoxication and ED admission of a 21-yr-old man following α-MT ingestion . He was hypertensive (BP 183/ninety three mmHg, coronary heart price fifty two bpm), had a excessive fever, felt disoriented, nervous and trembling. After medical remedy, the patient was discharged without complication. In the same 12 months, another α-MT intoxication concerned a 17-year-old male found bare and hallucinating . In the ED, he was hyperthermic and tachycardic (160 beats/min), introduced with fever (37.3 °C), sweating and reactive 6–7 mm mydriatic pupils.
There is an effective chance of nausea occurring in the course of the first half hour of the expertise nevertheless it seems to move comparatively rapidly for most people. As with different psychedelics it works greatest when you go into the expertise with an empty abdomen. There have been a number of reviews of muscle tightness and/or tremors just like what we now have seen with 4-acetoxy-DIPT and DPT. However the bodily side-effects noticed so far appear relatively benign.
Cannabis - Cannabis could have an unexpectedly strong and unpredictable synergy with the effects of 4-AcO-DET. Caution is advised with this combination as it can significantly enhance the risk of adverse psychological reactions like anxiety, paranoia, panic assaults, and psychosis. Users are suggested to begin off with only a fraction of their normal hashish dose and take long breaks between hits to avoid unintentional overdose. Although many psychoactive substances are fairly secure to make use of on their own, they will all of a sudden turn out to be dangerous and even life-threatening when mixed with different substances. The following list contains some identified dangerous combos . Independent analysis (e.g. Google, DuckDuckGo) should all the time be performed to make sure that a mixture of two or extra substances is secure to devour.
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Anecdotal stories from those who have tried four-AcO-DET suggests that there are no unfavorable health effects attributed to simply making an attempt the substance by itself at low to average doses and utilizing it very sparingly . Independent research ought to all the time be carried out to make sure that a combination of two or extra substances is safe before consumption. four-AcO-DET (four-Acetoxy-N,N-diethyltryptamine, ethacetin) is an obscure synthetic psychedelic tryptamine. There is very little data on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection. Today it's both used recreationally as a designer drug or as an entheogenic compound and is typically acquired through the usage of online research chemical vendors. It remains relatively uncommon and has little or no documented history of human utilization.
Table 2 summarizes the analytical strategies reported for the dedication of tryptamines in organic matrices, together with information on sample measurement, pattern preparation, instrumentation and validation parameters. In 2019, Grafinger et al. reported that a 32 yr old male went to the ED after the ingestion of an “LSD-like substance” . The reason for the intoxication was attributed to the mixed use of psychoactive substances. 5-MeO-MiPT was identified by LC-HR-MS/MS and quantified by liquid chromatography coupled with mass spectrometry in tandem (LC-MS/MS) at a hundred and sixty ng/mL in blood and 3380 ng/mL in urine. 5-MeO-DPT is a 5-MeO-DMT structural isomer obtainable as a white powder .
I was nonetheless the identical individual I all the time am, slightly below a different set of actuality issues. I had the Radiohead Kid A CD on the participant and about midway via it, I needed to substitute it with something more melodic. It was during this time that the twitching was at its most severe. I changed it with Steve Hillage's Fish Rising, a somewhat extra melodic if just as unique piece, which helped lots with the trembling. So, some three weeks later, I pyrolyzed ~15 mg , which I had heard was an efficient and potent dosage for this methodology. Pouring the rigorously measured 15 mg from the capsule onto a mattress of herbal material, it was coated with some extra herb material to make sufficient for one good inhalation, which was then ignited and inhaled.
4-AcO seems to be very closely associated to the magic mushroom compounds psilocybin and psilocin, and like psilocybin, is speculated to break down into psilocin within the physique throughout first move metabolism. In truth, 4-AcO-DMT was first synthesized in the early Sixties by Albert Hofmann, the same chemist who discovered LSD and first synthesized psilocybin. As an worker for the pharmaceutical company Sandoz, Hofmann and his colleague, Franz Troxler, were taking part in around with molecules similar to psilocin, and patented psilacetin along with four different esters of psilocin in 1963. Luethi, D.; Liechti, M.E. Monoamine transporter and receptor interplay profiles in vitro predict reported human doses of novel psychoactive stimulants and psychedelics. The effects of tryptamine administration are determined by their structures, as every compound has a special spectrum of receptor affinities and related psychoactive phenomena. In addition, the dose of tryptamine derivatives and length of their results generally differ among compounds and depend on their potency and route of administration .
Nothing I haven't experienced earlier than, however with a renewal and deepening that was wonderfully wholesome and strengthening. I noted that I actually have had related experiences with mescaline. Perhaps mystical experience is reserved for those who actively create it in their lives.
Tryptamine is found in hint quantities within the brains of mammals and is hypothesized to play a role as a neuromodulator or neurotransmitter. Similar to different hint amines, tryptamine binds to human hint amine-related receptor 1 as an agonist. nonetheless, the position of these interactions and how they outcome within the psychedelic expertise continues to stay elusive. four-aco-det is the n-substituted diethyl homolog of four-ho-dmt . 4-aco-det is the acetate ester analog of det and the n-substituted diethyl analog of 4-aco-dmt. I suspect that for psycholytic remedy presently involving LSD or 'shrooms, this substance may prove a favorite amongst therapists.
Yet, greater than 20 years later, there nonetheless haven’t been any clinical studies on the safety, toxicity, or potential efficacy of O-acetylpsilocin, regardless of its rising reputation among psychonauts. Different biological matrices had been employed for forensic purposes including typical matrices urine , blood , plasma serum and unconventional matrices oral fluid and hair . Protein precipitation is an easy sample preparation methodology, providing enough extraction efficiency whereas simplifying extraction and preparation time.
For protected dosing, remember to weigh out your dose on a scale that can read milligrams. And should you don’t personal one, you must consider investing. They don’t price greater than about $20 and are a simple approach to practice hurt discount.
No actual nausea to speak of, however I was conscious that something was going on. It is hard to characterize the effects of a brand new compound at Burning Man, because the surroundings is already so surreal. Nevertheless, if compelled to make comparisons, I would say that this stuff is very similar to psilocybian mushrooms. Indeed, I'd go as far as to say that with recognized doses of this as a pure compound available, I do not know that I'll ever want/wish to do mushrooms again. My "about 18 mg" dose was robust enough to get the complete taste of the effects, however not so strong to be overwhelming. If I was at residence or with a small group of associates, I would undoubtedly take the next dose, extra suited to a imaginative and prescient quest.
This tolerance additionally applies to other classic psychedelics. If taken with LSD or psilocybin mushrooms within every week, the expertise could be much much less pronounced than traditional. As with all tryptamines, 4 [1] 4-aco-det buy -AcO-DET has a core structure consisting of a bicyclic indole heterocycle connected at R3 to an amino group. It is an N-substituted diethyl homolog of psilocin (four-HO-DMT), with which it shares a number of chemical properties.
The free base is also lively when smoked in a dose range of 5–20 mg. 4-Acetoxy-N.N-diethyltryptamine, is a synthetic chemical of the tryptamine family and structurally related to 4-HO-DMT . Tryptamines share a core structure of a bicyclic indole heterocycle hooked up to an amino group through an ethyl side chain.
The test topics were not told something in regards to the nature of the drug and had no idea what to anticipate. Most of the topics weren't even aware of the existence of psychedelic drugs generally, as these experiments have been accomplished before the LSD hysteria of the '60s. The set and setting was minimized and all external stimuli avoided. After administration via intramuscular injection each topic was brought into a darkened room and asked to loosen up. This kind of protocol appears to supply a balanced picture of the general attainable physical and psychological results.
Troxler within the late 1950s (Hofmann 1958; Troxler et al. 1959). A few years later these compounds were offered to a number of German research scientists for analysis and testing underneath the path of Hofmann and A. Like with most psychedelic tryptamines, four-aco-det is thought to act principally as a 5-ht2a partial agonist.
In 2018, Honyiglo et al. described the death of an 18 yr old male in France who jumped from the second floor and died following “hallucinogenic mushroom” intake . The intoxication was confirmed by identification and quantification of psilocin in cardiac and femoral blood (sixty seven and 60 ng/mL respectively), urine (2230 ng/mL), bile (3102 ng/mL) and vitreous humor (57 ng/mL). Gas chromatography time-of-flight detection with electron influence ionization (GC-EI-TOF) was the analytical technique employed for identification and quantification. People also report mixing four-acetoxy-DMT with different psychedelics like LSD, MDMA, and ketamine. These mixes can also create very intense experiences with more pronounced visuals, but in addition extra possibilities for confusion, nausea, and delusions. In looking on the results of Leuner and Baer some observations may be made regarding the nature of CZ-74 and four-acetoxy-DET.
So when the opportunity to attempt 4-acetoxy-DET arrived, I was delighted. I was hanging out after darkish on the "Lush" camp, close to "Emerald City," waiting to listen to the band Lost at Last, whom I first heard a couple of year ago on the "Countdown to 2012" get together in San Francisco. I first observed that my stomach felt as if it was a rubber ball, being gripped firmly by two hands that were squeezing simply barely.
I was nonetheless a long way away from baseline after greater than 5 hours once I retired for the evening. I am not certain if this was due to the extremely taxing bodily nature of the experience or my getting old, but I am not used to hangovers from psychedelics. I wouldn't hesitate to do that substance again, however would use a smaller dose next time. I think it may be more fun with out some of the excessive effects, if they are often mitigated.
Ayahuasca is produced by mixing totally different vegetation by native populations of the basin of the Amazon river, suggested to be a drink with magic and healing powers. For the decoction preparation, the natives boil the bark or crushed stems of Banisteriopsis caapi along with different plants, together with the leaves of Psychotria viridis, a member of the Rubiaceae household. The two crops are distinguished by the content of energetic compounds. Psychotria viridis contains DMT and Banisteriopsis caapi accommodates harmala alkaloids harmine, tetrahydroharmine and harmaline .
This molecule is orally lively, with dose-dependent results. The commonest reported results included dizziness, elevated heart fee, tremor, anxiousness and agitation. four-AcO-DPT is the four-acetoxy by-product of DPT, is structurally just like 4-AcO-DMT and four-acetoxy-N, N- diisopropyltryptamine (four-AcO-DiPT) and is out there as a white powder . It is available on-line and typically administrated orally or by insufflation. Its results are dose dependent and embody hallucination, dissociation, confusion and flashbacks, as reported on Erowid by a four-AcO-DPT person . DiPT is an artificial hallucinogen, closely associated structurally to DMT, a 5HT2A agonist and a partial 5HT1A agonist that inhibits the serotonin transporter and vesicular monoamine transporter .
The visual factor is particularly putting with this materials. You will most likely enjoy a menagerie of rainbow visions and color hues. Music and sound could be extremely influential in creating a specific and desired impact--sound creates space. This is sort of evident by the numerous shamanic and mystical traditions that make use of sound to affect the course of consciousness.
No analytical confirmation was performed however a vial of DPT labelled “for analysis purposed solely” was discovered on the scene. MET is structurally associated to DMT but little scientific data is out there on its pharmacology or toxicity in humans. Inhalation of 15 mg freebase MET or 80–one hundred mg oral freebase MET produce effects . It is orally energetic as a result of the ethyl group prevents MAO degradation. The active dose is 50–100 mg, with psychoactive results lasting 2–4 h . DET’s most typical results embody slight generalized tremors to gross athletic actions, visible distortion, hypersensitivity to mild, visual hallucinations, auditory perceptual distortions and olfactory hallucinations .
Many nations report using psilocybin or magic mushrooms to the United Nations Office on Drugs and Crime . From the out there data on tendencies in using different substances from 2001–2017, nearly all of nations reported no vital change in psychedelic use over time. Furthermore, based on the 2019 Global Drug Survey , psychedelics were consumed by forty% of drug customers, with tryptamines the psychedelic class with the best improve in use. The psychedelics with the best prevalence of use were lysergic acid diethylamide (17.5%), psilocybin or magic mushrooms (14.eight%), DMT (four.2%), magic truffles (three.three%) and ayahuasca (1.1%) . Psychedelics are a diverse group of naturally occurring and artificial drugs that induce distorted states of consciousness, perception, pondering and feeling .
Recently, Holstege et al. reported the intoxication and ED admission of a 21-yr-old man following α-MT ingestion . He was hypertensive (BP 183/ninety three mmHg, coronary heart price fifty two bpm), had a excessive fever, felt disoriented, nervous and trembling. After medical remedy, the patient was discharged without complication. In the same 12 months, another α-MT intoxication concerned a 17-year-old male found bare and hallucinating . In the ED, he was hyperthermic and tachycardic (160 beats/min), introduced with fever (37.3 °C), sweating and reactive 6–7 mm mydriatic pupils.
There is an effective chance of nausea occurring in the course of the first half hour of the expertise nevertheless it seems to move comparatively rapidly for most people. As with different psychedelics it works greatest when you go into the expertise with an empty abdomen. There have been a number of reviews of muscle tightness and/or tremors just like what we now have seen with 4-acetoxy-DIPT and DPT. However the bodily side-effects noticed so far appear relatively benign.
Cannabis - Cannabis could have an unexpectedly strong and unpredictable synergy with the effects of 4-AcO-DET. Caution is advised with this combination as it can significantly enhance the risk of adverse psychological reactions like anxiety, paranoia, panic assaults, and psychosis. Users are suggested to begin off with only a fraction of their normal hashish dose and take long breaks between hits to avoid unintentional overdose. Although many psychoactive substances are fairly secure to make use of on their own, they will all of a sudden turn out to be dangerous and even life-threatening when mixed with different substances. The following list contains some identified dangerous combos . Independent analysis (e.g. Google, DuckDuckGo) should all the time be performed to make sure that a mixture of two or extra substances is secure to devour.
It is mandatory to procure person consent prior to running these cookies in your website. This web site uses cookies to enhance your experience whilst you navigate via the website. Out of those cookies, the cookies which are categorized as needed are saved in your browser as they're important for the working of fundamental functionalities of the web site. We also use third-get together cookies that assist us analyze and understand how you employ this website.
Anecdotal stories from those who have tried four-AcO-DET suggests that there are no unfavorable health effects attributed to simply making an attempt the substance by itself at low to average doses and utilizing it very sparingly . Independent research ought to all the time be carried out to make sure that a combination of two or extra substances is safe before consumption. four-AcO-DET (four-Acetoxy-N,N-diethyltryptamine, ethacetin) is an obscure synthetic psychedelic tryptamine. There is very little data on the human pharmacology or toxicity of 4-AcO-DET, although analytical methods have been developed for its detection. Today it's both used recreationally as a designer drug or as an entheogenic compound and is typically acquired through the usage of online research chemical vendors. It remains relatively uncommon and has little or no documented history of human utilization.
Checking Your Browser Before Accessing Tryptaminelabs Com.
Table 2 summarizes the analytical strategies reported for the dedication of tryptamines in organic matrices, together with information on sample measurement, pattern preparation, instrumentation and validation parameters. In 2019, Grafinger et al. reported that a 32 yr old male went to the ED after the ingestion of an “LSD-like substance” . The reason for the intoxication was attributed to the mixed use of psychoactive substances. 5-MeO-MiPT was identified by LC-HR-MS/MS and quantified by liquid chromatography coupled with mass spectrometry in tandem (LC-MS/MS) at a hundred and sixty ng/mL in blood and 3380 ng/mL in urine. 5-MeO-DPT is a 5-MeO-DMT structural isomer obtainable as a white powder .
I was nonetheless the identical individual I all the time am, slightly below a different set of actuality issues. I had the Radiohead Kid A CD on the participant and about midway via it, I needed to substitute it with something more melodic. It was during this time that the twitching was at its most severe. I changed it with Steve Hillage's Fish Rising, a somewhat extra melodic if just as unique piece, which helped lots with the trembling. So, some three weeks later, I pyrolyzed ~15 mg , which I had heard was an efficient and potent dosage for this methodology. Pouring the rigorously measured 15 mg from the capsule onto a mattress of herbal material, it was coated with some extra herb material to make sufficient for one good inhalation, which was then ignited and inhaled.
4-AcO seems to be very closely associated to the magic mushroom compounds psilocybin and psilocin, and like psilocybin, is speculated to break down into psilocin within the physique throughout first move metabolism. In truth, 4-AcO-DMT was first synthesized in the early Sixties by Albert Hofmann, the same chemist who discovered LSD and first synthesized psilocybin. As an worker for the pharmaceutical company Sandoz, Hofmann and his colleague, Franz Troxler, were taking part in around with molecules similar to psilocin, and patented psilacetin along with four different esters of psilocin in 1963. Luethi, D.; Liechti, M.E. Monoamine transporter and receptor interplay profiles in vitro predict reported human doses of novel psychoactive stimulants and psychedelics. The effects of tryptamine administration are determined by their structures, as every compound has a special spectrum of receptor affinities and related psychoactive phenomena. In addition, the dose of tryptamine derivatives and length of their results generally differ among compounds and depend on their potency and route of administration .
Nothing I haven't experienced earlier than, however with a renewal and deepening that was wonderfully wholesome and strengthening. I noted that I actually have had related experiences with mescaline. Perhaps mystical experience is reserved for those who actively create it in their lives.
Tryptamine is found in hint quantities within the brains of mammals and is hypothesized to play a role as a neuromodulator or neurotransmitter. Similar to different hint amines, tryptamine binds to human hint amine-related receptor 1 as an agonist. nonetheless, the position of these interactions and how they outcome within the psychedelic expertise continues to stay elusive. four-aco-det is the n-substituted diethyl homolog of four-ho-dmt . 4-aco-det is the acetate ester analog of det and the n-substituted diethyl analog of 4-aco-dmt. I suspect that for psycholytic remedy presently involving LSD or 'shrooms, this substance may prove a favorite amongst therapists.
Yet, greater than 20 years later, there nonetheless haven’t been any clinical studies on the safety, toxicity, or potential efficacy of O-acetylpsilocin, regardless of its rising reputation among psychonauts. Different biological matrices had been employed for forensic purposes including typical matrices urine , blood , plasma serum and unconventional matrices oral fluid and hair . Protein precipitation is an easy sample preparation methodology, providing enough extraction efficiency whereas simplifying extraction and preparation time.
For protected dosing, remember to weigh out your dose on a scale that can read milligrams. And should you don’t personal one, you must consider investing. They don’t price greater than about $20 and are a simple approach to practice hurt discount.
No actual nausea to speak of, however I was conscious that something was going on. It is hard to characterize the effects of a brand new compound at Burning Man, because the surroundings is already so surreal. Nevertheless, if compelled to make comparisons, I would say that this stuff is very similar to psilocybian mushrooms. Indeed, I'd go as far as to say that with recognized doses of this as a pure compound available, I do not know that I'll ever want/wish to do mushrooms again. My "about 18 mg" dose was robust enough to get the complete taste of the effects, however not so strong to be overwhelming. If I was at residence or with a small group of associates, I would undoubtedly take the next dose, extra suited to a imaginative and prescient quest.
This tolerance additionally applies to other classic psychedelics. If taken with LSD or psilocybin mushrooms within every week, the expertise could be much much less pronounced than traditional. As with all tryptamines, 4 [1] 4-aco-det buy -AcO-DET has a core structure consisting of a bicyclic indole heterocycle connected at R3 to an amino group. It is an N-substituted diethyl homolog of psilocin (four-HO-DMT), with which it shares a number of chemical properties.
The free base is also lively when smoked in a dose range of 5–20 mg. 4-Acetoxy-N.N-diethyltryptamine, is a synthetic chemical of the tryptamine family and structurally related to 4-HO-DMT . Tryptamines share a core structure of a bicyclic indole heterocycle hooked up to an amino group through an ethyl side chain.
The test topics were not told something in regards to the nature of the drug and had no idea what to anticipate. Most of the topics weren't even aware of the existence of psychedelic drugs generally, as these experiments have been accomplished before the LSD hysteria of the '60s. The set and setting was minimized and all external stimuli avoided. After administration via intramuscular injection each topic was brought into a darkened room and asked to loosen up. This kind of protocol appears to supply a balanced picture of the general attainable physical and psychological results.
Drug Prohibition Laws
Troxler within the late 1950s (Hofmann 1958; Troxler et al. 1959). A few years later these compounds were offered to a number of German research scientists for analysis and testing underneath the path of Hofmann and A. Like with most psychedelic tryptamines, four-aco-det is thought to act principally as a 5-ht2a partial agonist.
In 2018, Honyiglo et al. described the death of an 18 yr old male in France who jumped from the second floor and died following “hallucinogenic mushroom” intake . The intoxication was confirmed by identification and quantification of psilocin in cardiac and femoral blood (sixty seven and 60 ng/mL respectively), urine (2230 ng/mL), bile (3102 ng/mL) and vitreous humor (57 ng/mL). Gas chromatography time-of-flight detection with electron influence ionization (GC-EI-TOF) was the analytical technique employed for identification and quantification. People also report mixing four-acetoxy-DMT with different psychedelics like LSD, MDMA, and ketamine. These mixes can also create very intense experiences with more pronounced visuals, but in addition extra possibilities for confusion, nausea, and delusions. In looking on the results of Leuner and Baer some observations may be made regarding the nature of CZ-74 and four-acetoxy-DET.
So when the opportunity to attempt 4-acetoxy-DET arrived, I was delighted. I was hanging out after darkish on the "Lush" camp, close to "Emerald City," waiting to listen to the band Lost at Last, whom I first heard a couple of year ago on the "Countdown to 2012" get together in San Francisco. I first observed that my stomach felt as if it was a rubber ball, being gripped firmly by two hands that were squeezing simply barely.
I was nonetheless a long way away from baseline after greater than 5 hours once I retired for the evening. I am not certain if this was due to the extremely taxing bodily nature of the experience or my getting old, but I am not used to hangovers from psychedelics. I wouldn't hesitate to do that substance again, however would use a smaller dose next time. I think it may be more fun with out some of the excessive effects, if they are often mitigated.
Ayahuasca is produced by mixing totally different vegetation by native populations of the basin of the Amazon river, suggested to be a drink with magic and healing powers. For the decoction preparation, the natives boil the bark or crushed stems of Banisteriopsis caapi along with different plants, together with the leaves of Psychotria viridis, a member of the Rubiaceae household. The two crops are distinguished by the content of energetic compounds. Psychotria viridis contains DMT and Banisteriopsis caapi accommodates harmala alkaloids harmine, tetrahydroharmine and harmaline .
This molecule is orally lively, with dose-dependent results. The commonest reported results included dizziness, elevated heart fee, tremor, anxiousness and agitation. four-AcO-DPT is the four-acetoxy by-product of DPT, is structurally just like 4-AcO-DMT and four-acetoxy-N, N- diisopropyltryptamine (four-AcO-DiPT) and is out there as a white powder . It is available on-line and typically administrated orally or by insufflation. Its results are dose dependent and embody hallucination, dissociation, confusion and flashbacks, as reported on Erowid by a four-AcO-DPT person . DiPT is an artificial hallucinogen, closely associated structurally to DMT, a 5HT2A agonist and a partial 5HT1A agonist that inhibits the serotonin transporter and vesicular monoamine transporter .
The visual factor is particularly putting with this materials. You will most likely enjoy a menagerie of rainbow visions and color hues. Music and sound could be extremely influential in creating a specific and desired impact--sound creates space. This is sort of evident by the numerous shamanic and mystical traditions that make use of sound to affect the course of consciousness.
No analytical confirmation was performed however a vial of DPT labelled “for analysis purposed solely” was discovered on the scene. MET is structurally associated to DMT but little scientific data is out there on its pharmacology or toxicity in humans. Inhalation of 15 mg freebase MET or 80–one hundred mg oral freebase MET produce effects . It is orally energetic as a result of the ethyl group prevents MAO degradation. The active dose is 50–100 mg, with psychoactive results lasting 2–4 h . DET’s most typical results embody slight generalized tremors to gross athletic actions, visible distortion, hypersensitivity to mild, visual hallucinations, auditory perceptual distortions and olfactory hallucinations .
Many nations report using psilocybin or magic mushrooms to the United Nations Office on Drugs and Crime . From the out there data on tendencies in using different substances from 2001–2017, nearly all of nations reported no vital change in psychedelic use over time. Furthermore, based on the 2019 Global Drug Survey , psychedelics were consumed by forty% of drug customers, with tryptamines the psychedelic class with the best improve in use. The psychedelics with the best prevalence of use were lysergic acid diethylamide (17.5%), psilocybin or magic mushrooms (14.eight%), DMT (four.2%), magic truffles (three.three%) and ayahuasca (1.1%) . Psychedelics are a diverse group of naturally occurring and artificial drugs that induce distorted states of consciousness, perception, pondering and feeling .
