In rodents, the upper sensitivity can also be associated to a shorter plasma half-lifetime of T 4 than in humans as a result of appreciable variations between species within the transport proteins for thyroid hormones. In plasma, the T 4 half-life is about 12—24 h in rats vs 5—9 days in humans, and the serum levels of TSH are about 25 occasions larger in rodents than in humans.
Fifty per cent of survivors were sacrificed 1 week later, and blood and urine samples had been taken. Resorcinol showed a concentration-dependent increase in labelling index [ three H]thymidine , acanthosis, and papillomatosis. After software of an ointment containing To research the goitrogenic exercise of resorcinol, female Wistar rats were treated twice every day for 28 days by rubbing 6 g of an ointment containing Increased thyroid gland weights 2.
Determination of resorcinol conjugates within the h urine samples after 14 days of continuous product therapy confirmed that a maximal 23 mg 2. Assuming a physique weight of 64 kg IPCS, gives an publicity estimate of zero. In a report primarily based on client research data Gans, , underneath affordable maximum-use circumstances i.
Hence, an improved biodegradation rate ends in decreased risks for the surroundings. Regarding the results of resorcinol on aquatic species, the toxicity knowledge set contains quite a lot of species from different trophic ranges. Results from checks with completely different aquatic species from different trophic ranges are available for the acute toxicity of resorcinol to aquatic organisms.
More usual-use circumstances would lead to exposures of about zero. Further particulars weren't given.
Animals that died confirmed hyperaemia and distension of abdomen and intestine, while there have been no gross lesions at necropsy in survivors Flickinger, In another examine with CFY rats. Most of the studies are of adequate quality and acceptable for danger characterization purposes.
Resorcinol is thought to kind covalent bonds with haem Sessler et al. Effects on the thyroid gland have been reported both in animal research and in case-reviews in people. However, there are species variations within the susceptibility to goitrogens.